A Specialized Exosome to Reawaken Hair Follicle Cells
Current Hair Loss Treatments Are Inadequate
Existing therapies target external factors affecting hair growth (e.g., anti-androgen drugs like finasteride Propecia).
Current treatments have limited efficacy and unclear mechanisms of action (e.g., minoxidil Rogaine and platelet-rich plasma PRP). Most are not FDA-approved.
Treatment options are not suitable for all patients and can be invasive or require oral dosing (e.g., spironolactone, hair transplantation)
NuGenUSA Solution
How it works?
Hair follicle stem cells (HFSCs) undergo cycles of dormancy and activation to power hair growth.
In alopecia related to age, stress, hormones, and chemotherapy, hair follicle stem cells can become “stuck” in the dormant phase and unable to trigger hair growth. However, these stem cells are still present and viable.
Our exosome activates dormant hair follicle stem cells, restoring the regenerative capacity of the follicle and triggering new hair growth.
Anatomy of Hair Follicle
Sequences of hair growth via Dermal Papilla and Hair follicle Stem Cells
The stages of differentiation of dermal follicle stem cells (HFSCs) into hair are:
- Activation: The dermal papilla (DP) releases a signal that activates the hair of the HFSCs
- Proliferation and differentiation: The activated HFSCs proliferate and differentiate, forming the outer root sheath (ORS) and matrix.
- Formation of the inner root sheath and hair shaft: The matrix forms the inner root sheath and hair shaft
The hair growth cycle is a continuous process that consists of four phases:
- Anagen: The growth phase when a new hair shaft is grown
- Catagen: The regression phase
- Telogen: The resting phase
- Exogen: The shedding phase
Efficacy of the Dermal Papilla Exo
Hair Removal Cream was used to remove hair.
2E9 DP-EXP was injected subcutaneously in 10 different spots.
Efficacy of the Dermal Papilla Exo
Proposed MoA related to the efficacy of Dermal Papilla Exo
Different hair loss diseases we can target using exosomes
Where to start?
It is estimated that 1 BILLION individuals globally suffer from Different degrees of Alopecia.
Chemotherapy-induced alopecia (CIA)
It is estimated that 10MM people per year go through Chemotherapy.
Ways to make this product even more potent:
Dermal Papilla exosome can be mixed with MSC Exo to potentially utilize it for autoimmune-mediated Alopecia.
Dermal Papilla exosome can be mixed with HUVEC Exo to potentially make it more potent.
